Numerous treatments have been proposed. But the treatment of itch remains difficult and it depends on its etiology. The understanding of the pathophysiogeny of itch is necessary. Fortunately, many very interesting results of research have been reported in the recent years. `Pruritis` will explain the pathophysiogeny of itch, describe all causes, and give guidelines for management and treatment. TOC:Introduction - Definitions: Physiopathology: Pruritic pain and other abnormal sensations, Neuroanatomy of itch, Neurophysiology of itch, Itch and the brain, Itch mediators, Itch and psychopathology, Measurement of itch.-Different causes of itch: An overview, Dermatological causes of itch, Non dermatological of itch, Examinations for pruritus, Itch, infections and infestations, Itch and drugs, Renal itch, Hepatic itch, Endocrine itch, Hematologic and paraneoplastic itch, Neurogenic itch and paresthesia, Senile itch, Psychogenic itch, Rare causes of itch, Localized itch, Stomatodynia and vulvodynia.- Treatment: Topical treatments, Antihistamines, Other systemic treatments, Physical treatments, Psychological approach, Other treatments.